SANUSq: Liposomal PEA (Palmitoylethanolamide) - 250ml

For Chronic Pain and Inflammation

Current batch best before date: 31st October 2026

Country of origin: United Kingdom

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Main ingredients: (per 5ml serve) PEA (Levagen®+) 150 mg, Phospholipids not more than 500 mg. Ultra pure water, Glycerol, Potassium sorbate (preservative), D-alpha-tocopherol (anti-oxidant). Refer to label for full list of ingredients.

Suggested daily dosage: Take 5 ml per day, with meals. Shake the bottle well before each use. Do not use if seal is broken or missing.

Storage: Refrigerate after opening and consume within 90 days

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What is PEA?

PEA supplements have found immense popularity among people who suffer from chronic pain and those looking to find safer alternatives to opioid based medications that are highly addictive, not well-tolerated and come with a long list of dangerous side effects. PEA is a fatty acid amide naturally produced by the body and is also found naturally in foods such as egg yolks and peanuts.

Research shows that PEA has anti-inflammatory, pain-relieving, antimicrobial, and neuroprotective properties, making it an excellent supplement for pain control, inflammatory joint disorders, poor sleep, anxiety and immune health. It also helps in tissue healing and recovery.  

Health Benefits in a Nutshell of PEA Supplement

1. Reduces chronic pain
   
2. Controls inflammation
   
3. Relives pain in osteoarthritis 
   
4. Helps in neuropathic pain and fibromyalgia
   
5. Useful in lower back pain
   
6. Boosts immunity
   
7. Eases anxiety
   
8. Relaxes and improves sleep 
   
9. Improves brain health
   
10. Boosts exercise performance
    
11. Supports muscle recovery
    
12. Improves gut health    

Palmitoylethanolamide (PEA) is a chemical naturally produced by the body in response to inflammation, stress and injury. More specifically, PEA is a fatty acid amide that works through a number of direct and indirect mechanisms (such as by activating cannabinoid receptors and inhibiting the production of pro-inflammatory molecules) to reduce pain and inflammation, and help tissue repair.

PEA is biologically similar to anandamide, a signaling molecule in the endocannabinoid system (ECS). Our endocannabinoid system regulates many critical functions such as appetite, metabolism, learning, memory, sleep, mood, nerve function, pain perception, immunity and inflammatory responses, and plays a very important role in keeping the nervous system healthy and coordinated. PEA is considered as an extended part of the endocannabinoid system, and supports and activates the ECS system, thus playing a key role in controlling pain and inflammation, restoring cellular homeostasis and offering a wide range of health benefits. 

What are the health benefits of liposomal PEA Supplement?

1.    Reduces inflammation: PEA activates receptors in the endocannabinoid system involved in regulating immune and inflammatory responses. In addition, it inhibits the production of proteins and molecules that are known to trigger pain and inflammation. PEA is beneficial in irritable bowel syndrome (reduces abdominal pain) and inflammatory bowel diseases (controls intestinal inflammation).

2.    Effective in chronic pain: Chronic pain is a serious problem that affects a person on mental, physical and emotional levels, significantly reducing quality of life and productivity. Chronic pain sufferers can't eat, work or exercise properly and are more likely to develop conditions such as nutritional deficiencies, anxiety, depression and sleep disorders, which make the pain worse. PEA can be very effective in managing chronic pain due to its strong analgesic and anti-inflammatory properties. It is helpful in conditions such as osteoarthritis, lower back pain, fibromyalgia, migraines, sciatica, carpal tunnel syndrome and nerve pain.

3.    Relieves joint pain in osteoarthritis: Studies show that PEA supplements are effective in reducing joint pain and improving mobility in patients with knee osteoarthritis.

4.    Improves sleep and eases anxiety: PEA has a positive effect on sleep quality as it reduces pain and promotes an overall feeling of calm. In addition, PEA inhibits an enzyme involved in the breakdown of AEA, thus increasing the levels of AEA (Anandamide, a major endocannabinoid also known as "bliss molecule"). AEA is involved in regulating stress response, brain-reward pathways and emotional behaviour. This is one of the ways through which PEA helps ease anxiety and works as an anti-depressant. PEA also improves the levels of neurotransmitters, thus promoting good moods, healthy sleep and better stress response.

5.    Boosts immunity: PEA exerts strong anti-viral and anti-bacterial properties. It reduces the chances of catching a cold and also reduces the duration as well as the symptoms of cold such as fever and sore throat. In addition, it works as an anti-allergic as it blocks the release of histamine. 

Liposomal PEA supplements for better bio-availability 

The amount of PEA your body produces is not enough to combat chronic pain and inflammation. Typical PEA supplements do not offer desirable outcomes, as PEA has poor solubility in water, negatively affecting its bio-availability and absorption in the body. Liposomal PEA simply means that liposomes are used to encapsulate PEA molecules, thus improving its bioavailability and absorption. This advanced delivery system ensures that more PEA reaches the target cells.

Precautions and warnings 

High quality PEA formulations are safe to use, non-toxic and generally well-tolerated even in high doses. We don’t recommend PEA for pregnant and breastfeeding women. 

References:

1. Clayton et al. Palmitoylethanolamide: A Natural Compound for Health Management. Int J Mol Sci. 2021. 
   
2. Branković et al. Therapeutic Potential of Palmitoylethanolamide in Gastrointestinal Disorders. Antioxidants 2024
   
3. Lang-Illievich et al. Palmitoylethanolamide in the Treatment of Chronic Pain: A Systematic Review and Meta-Analysis of Double-Blind Randomized Controlled Trials. Nutrients. 2023. 
   
4. Steels et al. A double-blind randomized placebo controlled study assessing safety, tolerability and efficacy of palmitoylethanolamide for symptoms of knee osteoarthritis. Inflammopharmacology. 2019
   
5. Amanda Rao et al. Palmitoylethanolamide for sleep disturbance. A double-blind, randomised, placebo-controlled interventional study. Sleep Science and Practice. 2021. 
   

Disclaimer

Information on our websites, in our blogs and our emails are provided for informational purposes only, and have not been evaluated by the EMA, EFSA or FDA. It is not meant to substitute medical advice provided by your healthcare professional and is not intended to diagnose, treat, cure, or prevent any disease. Our products are intended for adults, 18 years of age and older. While PEA has been shown to have various health benefits, it is important to remember that supplements and dietary changes should be considered as part of an overall health plan and not as a substitute for professional medical treatment. Only a qualified healthcare practitioner can provide personalized advice and treatment plans based on your individual health needs and medical history, and you should seek advice from your healthcare professional before taking product(s) if you are pregnant or nursing.